Thymic tuft cells promote an IL-4-enriched medulla and shape thymocyte development

Nature. 2018 Jul;559(7715):627-631. doi: 10.1038/s41586-018-0345-2. Epub 2018 Jul 18.

Abstract

The thymus is responsible for generating a diverse yet self-tolerant pool of T cells1. Although the thymic medulla consists mostly of developing and mature AIRE+ epithelial cells, recent evidence has suggested that there is far greater heterogeneity among medullary thymic epithelial cells than was previously thought2. Here we describe in detail an epithelial subset that is remarkably similar to peripheral tuft cells that are found at mucosal barriers3. Similar to the periphery, thymic tuft cells express the canonical taste transduction pathway and IL-25. However, they are unique in their spatial association with cornified aggregates, ability to present antigens and expression of a broad diversity of taste receptors. Some thymic tuft cells pass through an Aire-expressing stage and depend on a known AIRE-binding partner, HIPK2, for their development. Notably, the taste chemosensory protein TRPM5 is required for their thymic function through which they support the development and polarization of thymic invariant natural killer T cells and act to establish a medullary microenvironment that is enriched in the type 2 cytokine, IL-4. These findings indicate that there is a compartmentalized medullary environment in which differentiation of a minor and highly specialized epithelial subset has a non-redundant role in shaping thymic function.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • AIRE Protein
  • Animals
  • Cellular Microenvironment
  • Doublecortin-Like Kinases
  • Epithelial Cells / cytology*
  • Epithelial Cells / metabolism*
  • Female
  • Humans
  • Immune Tolerance / immunology
  • Interleukin-4 / biosynthesis
  • Interleukin-4 / metabolism*
  • Interleukins / metabolism
  • Intracellular Signaling Peptides and Proteins / metabolism
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Mice, Inbred C57BL
  • Protein Serine-Threonine Kinases / metabolism
  • TRPM Cation Channels / metabolism
  • Thymocytes / cytology*
  • Thymocytes / metabolism
  • Thymus Gland / anatomy & histology
  • Thymus Gland / cytology*
  • Thymus Gland / metabolism*
  • Transcription Factors / deficiency
  • Transcription Factors / genetics

Substances

  • Interleukins
  • Intracellular Signaling Peptides and Proteins
  • Mydgf protein, mouse
  • TRPM Cation Channels
  • TRPM5 protein, human
  • Transcription Factors
  • Interleukin-4
  • DCLK1 protein, human
  • Doublecortin-Like Kinases
  • Dclk1 protein, mouse
  • Protein Serine-Threonine Kinases