Abstract
In the present study we show that peritoneal macrophages obtained from the mice treated with the immunoactive peptides inhibit the multiplication of Herpes simplex virus type 1 (HSV-1) and type 2 (HSV-2), but not that of vesicular stomatitis virus (VSV), and that the intraperitoneal administration of the peptides suppresses the infection with HSV-1 in mice.
MeSH terms
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Adjuvants, Immunologic
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Animals
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DNA Replication*
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Female
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Macrophages / drug effects
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Macrophages / immunology*
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Mice
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Mice, Inbred ICR
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Oligopeptides / pharmacology*
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Simplexvirus / genetics*
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Structure-Activity Relationship
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Vesicular stomatitis Indiana virus / genetics*
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Virus Replication
Substances
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Adjuvants, Immunologic
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Oligopeptides
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FR 48217
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heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine