Abstract
Mouse models have been invaluable for delineating the contributions of specific genes and signaling pathways to the pathogenesis of cardiac arrhythmias. Considering that there are important differences between mice and humans, here we discuss the strengths and limitations of mouse models of cardiac arrhythmias.
Keywords:
atrial fibrillation; cell lines; gene targeting; mice; oocytes.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Arrhythmias, Cardiac / genetics*
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Arrhythmias, Cardiac / metabolism
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Arrhythmias, Cardiac / physiopathology
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Arrhythmias, Cardiac / therapy
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Disease Models, Animal*
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Heart / physiology
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Heart / physiopathology
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Mice
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Myocardium / metabolism
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Translational Research, Biomedical / methods