Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study

Luisa Salazar-Vizcaya; Gilles Wandeler; Jan Fehr; Dominique Braun; Matthias Cavassini; Marcel Stoeckle; Enos Bernasconi; Matthias Hoffmann; Mathieu Rougemont; Charles Béguelin; Andri Rauch; Swiss HIV Cohort Study

doi:10.1093/ofid/ofy154

Impact of Direct-Acting Antivirals on the Burden of HCV Infection Among Persons Who Inject Drugs and Men Who Have Sex With Men in the Swiss HIV Cohort Study

Open Forum Infect Dis. 2018 Jun 26;5(7):ofy154. doi: 10.1093/ofid/ofy154. eCollection 2018 Jul.

Authors

Luisa Salazar-Vizcaya¹, Gilles Wandeler^{1

2}, Jan Fehr^{3

4}, Dominique Braun^{3

5

6}, Matthias Cavassini^{5

6}, Marcel Stoeckle⁷, Enos Bernasconi⁸, Matthias Hoffmann⁹, Mathieu Rougemont¹⁰, Charles Béguelin¹, Andri Rauch¹; Swiss HIV Cohort Study

Collaborators

Swiss HIV Cohort Study:
V Aubert, M Battegay, E Bernasconi, J Böni, D L Braun, H C Bucher, A Calmy, M Cavassini, A Ciuffi, G Dollenmaier, M Egger, L Elzi, J Fehr, J Fellay, H Furrer, C A Fux, H F Günthard, D Haerry, B Hasse, H H Hirsch, M Hoffmann, I Hösli, C Kahlert, L Kaiser, O Keiser, T Klimkait, R D Kouyos, H Kovari, B Ledergerber, G Martinetti, B Martinez de Tejada, C Marzolini, K J Metzner, N Müller, D Nicca, G Pantaleo, P Paioni, A Rauch, C Rudin, A U Scherrer, P Schmid, R Speck, M Stöckle, P Tarr, A Trkola, P Vernazza, G Wandeler, R Weber, S Yerly

Affiliations

¹ Department of Infectious Diseases, Bern University Hospital, University of Bern, Bern, Switzerland.
² Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
³ Division of Infectious Diseases and Hospital Epidemiology, University Hospital Zurich, Zurich, Switzerland.
⁴ Department of Public Health, Epidemiology, Biostatistic and Prevention Institute, University of Zurich, Zurich, Switzerland.
⁵ Institute of Medical Virology, University of Zurich, Zurich, Switzerland.
⁶ Division of Infectious Diseases, University Hospital Lausanne, University of Lausanne, Lausanne, Switzerland.
⁷ Department of Infectious Diseases and Hospital Hygiene, University Hospital Basel, Basel, Switzerland.
⁸ Division of Infectious Diseases, Regional Hospital Lugano, Lugano, Switzerland.
⁹ Division of Infectious Diseases and Hospital Epidemiology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland.
¹⁰ Division of Infectious Diseases, University Hospital Geneva, University of Geneva, Geneva, Switzerland.

Abstract

In the Swiss HIV Cohort Study, the number of people who inject drugs with replicating hepatitis C virus (HCV) infection decreased substantially after the introduction of direct-acting antivirals (DAAs). Among men who have sex with men, the increase in DAA uptake and efficacy was counterbalanced by frequent incident HCV infections.

Keywords: DAA; HCV; MSM; PWID; viral replication.