PD-1 is highly expressed by neoplastic B-cells in Richter transformation

Br J Haematol. 2019 Apr;185(2):370-373. doi: 10.1111/bjh.15514. Epub 2018 Jul 20.

Authors

Amir Behdad¹, Brannan Griffin¹, Yi-Hua Chen¹, Shuo Ma², Katalin Kelemen³, Xinyan Lu¹, Qing C Chen¹

Affiliations

¹ Department of Pathology, Northwestern University Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.
² Division of Hematology/Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine and the Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL, USA.
³ Department of Pathology, Mayo Clinic, Phoenix, AZ, USA.

PMID: 30028010
DOI: 10.1111/bjh.15514

No abstract available

Keywords: chronic lymphocytic leukaemia; PD-1 (PDCD1); PD-L1 (CD274); Richter syndrome.

MeSH terms

Adult
Aged
Aged, 80 and over
B-Lymphocytes / metabolism*
B7-H1 Antigen / metabolism
Biomarkers, Tumor / metabolism
Cell Transformation, Neoplastic / immunology*
Cell Transformation, Neoplastic / pathology
Disease Progression
Female
Humans
Leukemia, Lymphocytic, Chronic, B-Cell / immunology*
Leukemia, Lymphocytic, Chronic, B-Cell / pathology
Lymphoma, Large B-Cell, Diffuse / immunology*
Lymphoma, Large B-Cell, Diffuse / pathology
Male
Middle Aged
Programmed Cell Death 1 Receptor / metabolism*

Substances

B7-H1 Antigen
Biomarkers, Tumor
CD274 protein, human
PDCD1 protein, human
Programmed Cell Death 1 Receptor