Abstract
On the basis of the reported slow channel-inhibiting activity of oximes and phosphonates a series of compounds bearing such functions on lipophilic carriers were synthesized and studied. Among the compounds studied only (VI b) shows a slight cardiovascular activity. The surprising lack of activity of diethyl 3,4-dimethoxybenzyl-phosphonate (XIV), which is closely related to Fostedil, is discussed.
MeSH terms
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Animals
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Calcium Channel Blockers / chemical synthesis*
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Chemical Phenomena
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Chemistry
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Coronary Circulation / drug effects
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Guinea Pigs
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Heart / drug effects
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Heart Rate / drug effects
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Hemodynamics / drug effects
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In Vitro Techniques
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Oximes / chemical synthesis*
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Oximes / pharmacology
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Phosphorus Acids / chemical synthesis*
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Phosphorus Acids / pharmacology
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Verapamil / pharmacology
Substances
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Calcium Channel Blockers
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Oximes
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Phosphorus Acids
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Verapamil