Abstract
Three new human lambda L chain-like Ig genes are identified by restriction enzyme and nucleotide sequence analysis. Two genes, 14.1 and 16.1, have intact J and C regions, and are potentially functional, with open reading frames. A third gene, 18.1, is a pseudogene. The evolutionary lineage of these genes compared to the known functional locus lambda C1-lambda C6 can be surmised from Southern blot and nucleotide homologies. This study demonstrates that the human lambda gene family is more complex than previously recognized.
Publication types
-
Research Support, Non-U.S. Gov't
-
Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
-
Amino Acid Sequence
-
Base Sequence
-
Chromosomes, Human, 21-22 and Y
-
DNA / genetics
-
DNA Restriction Enzymes
-
Genes*
-
Humans
-
Immunoglobulin Constant Regions / genetics
-
Immunoglobulin J-Chains / genetics
-
Immunoglobulin Light Chains / genetics*
-
Immunoglobulin lambda-Chains / classification
-
Immunoglobulin lambda-Chains / genetics*
-
Sequence Homology, Nucleic Acid
Substances
-
Immunoglobulin Constant Regions
-
Immunoglobulin J-Chains
-
Immunoglobulin Light Chains
-
Immunoglobulin lambda-Chains
-
DNA
-
DNA Restriction Enzymes
Associated data
-
GENBANK/M12810
-
GENBANK/M12811
-
GENBANK/M12812
-
GENBANK/M12988
-
GENBANK/M12989