The miR-200 family: multiple effects on gliomas

Lilei Peng; Jie Fu; Yang Ming

doi:10.2147/CMAR.S160945

The miR-200 family: multiple effects on gliomas

Cancer Manag Res. 2018 Jul 13:10:1987-1992. doi: 10.2147/CMAR.S160945. eCollection 2018.

Authors

Lilei Peng¹, Jie Fu², Yang Ming¹

Affiliations

¹ Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People's Republic of China, [email protected].
² Department of Neurology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, People's Republic of China.

Abstract

Gliomas are the most common type of primary brain tumors. MicroRNAs (miRNAs) are small noncoding RNAs that can epigenetically regulate target gene expression. The microRNA 200 family includes miR-200a, 200b, 200c, 141 and 429. Numerous studies have indicated that members of the miR-200 family play an important role in glioma development and metastasis. In this review, we summarize the data from various studies and highlight the effects of miR-200 on glioma metastasis, therapeutic response and prognosis.

Keywords: chemoresistance; glioma; metastasis; miR-200 family; radioresistance.

Publication types

Review