MDM2 controls gene expression independently of p53 in both normal and cancer cells

Cell Death Differ. 2018 Sep;25(9):1533-1535. doi: 10.1038/s41418-018-0156-x. Epub 2018 Jul 23.
No abstract available

MeSH terms

  • Animals
  • DNA Damage
  • Gene Expression Regulation*
  • Genomic Instability
  • Humans
  • Mice
  • Mice, Knockout
  • NADH Dehydrogenase / genetics
  • NADH Dehydrogenase / metabolism
  • Neoplasms / metabolism
  • Neoplasms / pathology*
  • Proto-Oncogene Proteins c-mdm2 / genetics
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • RNA Stability
  • Tumor Suppressor Protein p53 / genetics
  • Tumor Suppressor Protein p53 / metabolism*
  • Ubiquitination

Substances

  • Tumor Suppressor Protein p53
  • MT-ND6 protein, human
  • NADH Dehydrogenase
  • Proto-Oncogene Proteins c-mdm2