Use of an Alpha-1 Adrenoreceptor Agonist in the Management of Recurrent Refractory Idiopathic Chylothorax

Parthipan Sivakumar; Liju Ahmed

doi:10.1016/j.chest.2018.02.005

Use of an Alpha-1 Adrenoreceptor Agonist in the Management of Recurrent Refractory Idiopathic Chylothorax

Chest. 2018 Jul;154(1):e1-e4. doi: 10.1016/j.chest.2018.02.005.

Authors

Parthipan Sivakumar¹, Liju Ahmed²

Affiliations

¹ Department of Thoracic Medicine, Guy's and St Thomas' NHS Foundation Trust, London, England. Electronic address: [email protected].
² Department of Thoracic Medicine, Guy's and St Thomas' NHS Foundation Trust, London, England.

PMID: 30044748
DOI: 10.1016/j.chest.2018.02.005

Abstract

A 70-year-old woman presents with recurrent idiopathic chylothorax refractory to both medical and surgical treatment. To our knowledge, this is the first reported case where midodrine, an alpha-1 receptor agonist, was used as an adjunctive therapy for idiopathic chylothorax resulting in both a radiographic and clinical response.

Keywords: adrenergic agents; chyle; chylothorax; midodrine; pleural effusion.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adrenergic alpha-1 Receptor Agonists / therapeutic use
Aged
Chylothorax / diagnosis
Chylothorax / drug therapy*
Chylothorax / surgery
Female
Follow-Up Studies
Humans
Midodrine / therapeutic use*
Radiography, Thoracic
Recurrence
Thoracoscopy

Substances

Adrenergic alpha-1 Receptor Agonists
Midodrine