Asperlicin, a novel non-peptidal cholecystokinin antagonist from Aspergillus alliaceus. Fermentation, isolation and biological properties

J Antibiot (Tokyo). 1985 Dec;38(12):1633-7. doi: 10.7164/antibiotics.38.1633.

Abstract

The fermentation and isolation of a new, non-peptide cholecystokinin antagonist, asperlicin, produced by Aspergillus alliaceus is described. The potent and specific interaction of asperlicin with cholecystokinin receptors was shown using in vitro biochemical assays.

MeSH terms

  • Animals
  • Anti-Bacterial Agents / isolation & purification*
  • Anti-Bacterial Agents / pharmacology
  • Aspergillus / metabolism*
  • Benzodiazepinones / isolation & purification*
  • Benzodiazepinones / pharmacology
  • Chemical Phenomena
  • Chemistry
  • Cholecystokinin / antagonists & inhibitors*
  • Fermentation
  • In Vitro Techniques
  • Rats
  • Receptors, Cell Surface / drug effects*
  • Receptors, Cell Surface / metabolism
  • Receptors, Cholecystokinin

Substances

  • Anti-Bacterial Agents
  • Benzodiazepinones
  • Receptors, Cell Surface
  • Receptors, Cholecystokinin
  • Cholecystokinin
  • asperlicin