Persistent Zika virus infection in porcine conceptuses is associated with elevated in utero cortisol levels

Ivan Trus; Joseph Darbellay; Yanyun Huang; Matthew Gilmour; David Safronetz; Volker Gerdts; Uladzimir Karniychuk

doi:10.1080/21505594.2018.1504558

Persistent Zika virus infection in porcine conceptuses is associated with elevated in utero cortisol levels

Virulence. 2018;9(1):1338-1343. doi: 10.1080/21505594.2018.1504558.

Authors

Ivan Trus¹, Joseph Darbellay¹, Yanyun Huang², Matthew Gilmour³, David Safronetz³, Volker Gerdts^{1

4}, Uladzimir Karniychuk^{1

4

5}

Affiliations

¹ a Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan , Saskatoon , Canada.
² b Prairie Diagnostic Services , Saskatoon , Canada.
³ c Canada National Microbiology Laboratory, Public Health Agency of Canada , Winnipeg , Canada.
⁴ d Department of Veterinary Microbiology , Western College of Veterinary Medicine, University of Saskatchewan , Saskatoon , Canada.
⁵ e School of Public Health , University of Saskatchewan , Saskatoon , Canada.

No abstract available

Keywords: 11β-HSD; HPA axis; Zika virus; cortisol; fetus; pig; placenta.

Publication types

Letter
Research Support, Non-U.S. Gov't

MeSH terms

Amniotic Fluid / chemistry*
Animals
Female
Fetus / virology
Hydrocortisone / analysis*
Placenta / chemistry
Placenta / virology
Pregnancy
Swine
Uterus / chemistry*
Uterus / virology
Zika Virus Infection / veterinary*

Substances

Hydrocortisone

Grants and funding

Financial support was provided by Genome Canada (Emerging Issue Program grant #418402), the Public Health Agency of Canada and the Government of Saskatchewan (Innovation Saskatchewan grant #418836). This paper was published with the permission of the Director of VIDO-InterVac, manuscript #829.