Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques

Alexandra M Ortiz; Jacob K Flynn; Sarah R DiNapoli; Ivan Vujkovic-Cvijin; Carly E Starke; Stephen H Lai; MacKenzie E Long; Ornella Sortino; Carol L Vinton; Joseph C Mudd; Leslie Johnston; Kathleen Busman-Sahay; Yasmine Belkaid; Jacob D Estes; Jason M Brenchley

doi:10.1038/s41591-018-0132-5

Experimental microbial dysbiosis does not promote disease progression in SIV-infected macaques

Nat Med. 2018 Sep;24(9):1313-1316. doi: 10.1038/s41591-018-0132-5. Epub 2018 Jul 30.

Authors

Alexandra M Ortiz¹, Jacob K Flynn¹, Sarah R DiNapoli¹, Ivan Vujkovic-Cvijin², Carly E Starke¹, Stephen H Lai¹, MacKenzie E Long¹, Ornella Sortino¹, Carol L Vinton¹, Joseph C Mudd¹, Leslie Johnston³, Kathleen Busman-Sahay^{3

4}, Yasmine Belkaid^{2

5}, Jacob D Estes^{3

4

6}, Jason M Brenchley⁷

Affiliations

¹ Barrier Immunity Section, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA.
² Mucosal Immunology Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD, USA.
³ AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Inc., Frederick, MD, USA.
⁴ Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, OR, USA.
⁵ NIAID Microbiome Program, NIH, Bethesda, MD, USA.
⁶ Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR, USA.
⁷ Barrier Immunity Section, Laboratory of Viral Diseases, National Institutes of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD, USA. [email protected].

Abstract

Intestinal microbial dysbiosis has been described in individuals with an HIV-1 infection and may underlie persistent inflammation in chronic infection, thereby contributing to disease progression. Herein, we induced an HIV-1-like intestinal dysbiosis in rhesus macaques (Macaca mulatta) with vancomycin treatment and assessed the contribution of dysbiosis to SIV disease progression. Dysbiotic and control animals had similar disease progression, indicating that intestinal microbial dysbiosis similar to that observed in individuals with HIV is not sufficient to accelerate untreated lentiviral disease progression.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Disease Progression*
Dysbiosis / microbiology*
Macaca mulatta
Male
Simian Acquired Immunodeficiency Syndrome / microbiology*
Simian Acquired Immunodeficiency Syndrome / virology*
Simian Immunodeficiency Virus / physiology*
Vancomycin / pharmacology

Substances

Vancomycin

Grants and funding

P51 OD011092/OD/NIH HHS/United States