•The comprehensive echocardiographic evaluation of a large, atypical left ventricular mass is presented.•The case highlights the importance of careful assessment from multiple imaging planes, using both transthoracic and transesophageal imaging, in order to accurately characterize an intracardiac mass on echocardiography.•In certain cases where further characterization of an intracardiac mass is required, cardiac magnetic resonance imaging could assist in differentiating cardiac thrombus from cardiac tumors.
Keywords: Intracardiac mass; Left ventricular thrombus; Mural endocarditis; Transesophageal echocardiography; Transthoracic echocardiography.