Caught in the "Akt": Cross-talk between EphA2 and EGFR through the Akt-PIKfyve axis maintains cellular sensitivity to EGF

Sci Signal. 2018 Jul 31;11(541):eaau1207. doi: 10.1126/scisignal.aau1207.

Abstract

Activation of EGFR (epidermal growth factor receptor) and Eph receptor often exerts opposing effects on cell functions. In this issue of Science Signaling, Stallaert et al reveal how cells maintain sustained response to EGF stimulation by replenishing EGFR at the plasma membrane and how conflicting signals from the EphA-ephrin system and EGFR are integrated to coordinate cellular responses, including cell migration and proliferation.

Publication types

  • Research Support, N.I.H., Extramural
  • Review
  • Comment

MeSH terms

  • Cell Movement
  • Epidermal Growth Factor*
  • ErbB Receptors*
  • Proto-Oncogene Proteins c-akt
  • Signal Transduction

Substances

  • Epidermal Growth Factor
  • ErbB Receptors
  • Proto-Oncogene Proteins c-akt