Near Full-Length Genomic Characterization of a Novel HIV Type 1 Recombinant Form (CRF01_AE/B) Identified from Anhui, China

AIDS Res Hum Retroviruses. 2018 Dec;34(12):1100-1105. doi: 10.1089/AID.2018.0144. Epub 2018 Sep 18.

Abstract

HIV-1 recombinant forms contribute substantially to its genetic evolution. This study reports a novel HIV-1 second-generation recombinant form (AH150299) composed of CRF01_AE and subtype B, isolated from an HIV-positive female subject infected through heterosexual contact in Anhui province of eastern China. The analyses of the near full-length genome sequence showed that one subtype B segment was inserted into the CRF01_AE backbone, with two recombinant breakpoints observed in the vif/vpr and env/nef gene regions. Phylogenetic analysis demonstrated that the CRF01_AE region of the recombinant belongs to CRF01_AE cluster 4, and the B subregions were correlated with the B strains circulating among men who have sex with men in China. In recent years, the emergence of novel recombinant strains reflected the complexity of the HIV-1 epidemic in Anhui, suggesting the significance of continuous monitoring of the dynamic transmissions of HIV-1 in eastern China.

Keywords: Anhui; CRF01_AE/B; China; HIV-1; recombinant form.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acquired Immunodeficiency Syndrome / epidemiology*
  • Acquired Immunodeficiency Syndrome / genetics*
  • Acquired Immunodeficiency Syndrome / transmission
  • Acquired Immunodeficiency Syndrome / virology
  • Base Sequence / genetics
  • China / epidemiology
  • Epidemics*
  • Female
  • Genes, Viral / genetics*
  • Genome, Viral / genetics*
  • Genotype
  • HIV-1 / genetics*
  • Homosexuality, Male
  • Humans
  • Male
  • Middle Aged
  • Phylogeny
  • Prevalence
  • Recombination, Genetic*
  • Sexual and Gender Minorities