Helicobacter pylori and extragastric diseases: A review

World J Gastroenterol. 2018 Aug 7;24(29):3204-3221. doi: 10.3748/wjg.v24.i29.3204.

Abstract

Helicobacter pylori (H. pylori) infection is very common and affects approximately half of the world population. It causes gastric diseases, but some authors have reported an association of H. pylori infection with other systemic manifestations beginning in 1994. The list of potential effects of H. pylori outside the stomach includes a number of extragastric manifestations and we focused on neurological, dermatological, hematologic, ocular, cardiovascular, metabolic, allergic, and hepatobiliary diseases. This review discusses these important reported manifestations that are not related to the gastrointestinal tract.

Keywords: Allergic diseases; Cardiovascular diseases; Dermatological diseases; Extragastric disease; Helicobacter pylori; Hematologic diseases; Hepatobiliary diseases; Metabolic diseases; Neurological diseases; Ocular diseases.

Publication types

  • Review

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Anti-Bacterial Agents / therapeutic use*
  • Cardiovascular Diseases / epidemiology
  • Cardiovascular Diseases / etiology
  • Cardiovascular Diseases / prevention & control
  • Eye Diseases / epidemiology
  • Eye Diseases / etiology
  • Eye Diseases / prevention & control
  • Helicobacter Infections / complications*
  • Helicobacter Infections / drug therapy
  • Helicobacter Infections / immunology
  • Helicobacter Infections / microbiology
  • Helicobacter pylori / drug effects
  • Helicobacter pylori / immunology
  • Helicobacter pylori / isolation & purification
  • Helicobacter pylori / pathogenicity*
  • Hematologic Diseases / epidemiology
  • Hematologic Diseases / etiology
  • Hematologic Diseases / prevention & control
  • Humans
  • Hypersensitivity / epidemiology
  • Hypersensitivity / etiology
  • Hypersensitivity / prevention & control
  • Metabolic Diseases / epidemiology
  • Metabolic Diseases / etiology
  • Metabolic Diseases / prevention & control
  • Nervous System Diseases / epidemiology
  • Nervous System Diseases / etiology
  • Nervous System Diseases / prevention & control
  • Risk Factors
  • Skin Diseases / epidemiology
  • Skin Diseases / etiology
  • Skin Diseases / prevention & control
  • Treatment Outcome

Substances

  • Anti-Bacterial Agents