Phytochemicals in Helicobacter pylori Infections: What Are We Doing Now?

Int J Mol Sci. 2018 Aug 10;19(8):2361. doi: 10.3390/ijms19082361.

Abstract

In this critical review, plant sources used as effective antibacterial agents against Helicobacter pylori infections are carefully described. The main intrinsic bioactive molecules, responsible for the observed effects are also underlined and their corresponding modes of action specifically highlighted. In addition to traditional uses as herbal remedies, in vitro and in vivo studies focusing on plant extracts and isolated bioactive compounds with anti-H. pylori activity are also critically discussed. Lastly, special attention was also given to plant extracts with urease inhibitory effects, with emphasis on involved modes of action.

Keywords: Helicobacter pylori; anti-urease activity; in vitro/in vivo findings; opportunistic colonization; phytopharmacology; plant products.

Publication types

  • Review

MeSH terms

  • Animals
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / metabolism
  • Helicobacter Infections / drug therapy*
  • Helicobacter Infections / enzymology
  • Helicobacter Infections / pathology
  • Helicobacter pylori / enzymology*
  • Humans
  • Phytotherapy*
  • Plant Extracts / therapeutic use*
  • Urease / antagonists & inhibitors*
  • Urease / metabolism

Substances

  • Bacterial Proteins
  • Plant Extracts
  • Urease