Long non-coding RNAs expression levels in diffuse large B-cell lymphoma: An in silico analysis

Fatemeh Dousti; Arman Shahrisa; Hossein Ansari; Mohammadreza Hajjari; Yaser Tahmasebi Birgani; Javad Mohammadiasl; Maryam Tahmasebi Birgani

doi:10.1016/j.prp.2018.08.006

Long non-coding RNAs expression levels in diffuse large B-cell lymphoma: An in silico analysis

Pathol Res Pract. 2018 Sep;214(9):1462-1466. doi: 10.1016/j.prp.2018.08.006. Epub 2018 Aug 7.

Authors

Fatemeh Dousti¹, Arman Shahrisa², Hossein Ansari³, Mohammadreza Hajjari⁴, Yaser Tahmasebi Birgani⁵, Javad Mohammadiasl⁶, Maryam Tahmasebi Birgani⁷

Affiliations

¹ Department of Immunology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
² Department of Molecular Genetics, Faculty of Biosciences, Tarbiat Modares University, Tehran, Iran.
³ Departments of Biotechnology, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran. Electronic address: [email protected].
⁴ Department of Genetics, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.
⁵ Department of Environmental Health Engineering, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Environmental Technologies Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁶ Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
⁷ Department of Medical Genetics, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran; Cellular and Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Iran. Electronic address: [email protected].

PMID: 30104077
DOI: 10.1016/j.prp.2018.08.006

Abstract

Long non-coding RNAs (lncRNAs), are lengthy noncoding transcripts with pivotal roles in biological pathways including cell cycle, apoptosis and chromatin remodeling. Aberrant expression of lncRNAs has been strongly connected with tumor progression and metastasis. However, the prognostic significance of lncRNAs in diffuse large-B-cell lymphoma (DLBCL) remains unclear. In this study, the expression levels of 189 approved lncRNAs were considered in DLBCL patients using several different genomic and transcriptome datasets. The analyses showed that the lncRNA GAS5 allocated the maximum score of RNA dysregulation and can be considered as good choice in DLBCLs' researches.

Keywords: Bioinformatics analysis; Biomarker; Diffuse large-B-cell lymphoma; GAS5; Long noncoding RNA.

MeSH terms

Computer Simulation
Humans
Lymphoma, Large B-Cell, Diffuse / genetics*
Lymphoma, Large B-Cell, Diffuse / pathology*
RNA, Long Noncoding / genetics*
Transcriptome

Substances

GAS5 long non-coding RNA, human
RNA, Long Noncoding