A comparative study of dissolving hyaluronic acid microneedles with trehalose and poly(vinyl pyrrolidone) for efficient peptide drug delivery

Biomater Sci. 2018 Sep 25;6(10):2566-2570. doi: 10.1039/c8bm00768c.

Abstract

We studied the role of the additives trehalose and poly(vinyl pyrrolidone) in the physical and pharmacokinetic properties of peptide drug incorporated hyaluronic acid microneedles. Poly(vinyl pyrrolidone) increases the mechanical strength of microneedles and ameliorates drug bioavailability in vivo, suggesting that poly(vinyl pyrrolidone) can be a promising additive in the fabrication of peptide drug-encapsulated fully dissolving microneedles.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Drug Delivery Systems*
  • Hyaluronic Acid / administration & dosage*
  • Hyaluronic Acid / chemistry
  • Hyaluronic Acid / pharmacokinetics
  • Microinjections
  • Needles*
  • Parathyroid Hormone / administration & dosage*
  • Parathyroid Hormone / blood
  • Parathyroid Hormone / chemistry
  • Parathyroid Hormone / pharmacokinetics
  • Povidone / administration & dosage*
  • Povidone / chemistry
  • Povidone / pharmacokinetics
  • Rats
  • Trehalose / administration & dosage*
  • Trehalose / chemistry
  • Trehalose / pharmacokinetics

Substances

  • Parathyroid Hormone
  • Hyaluronic Acid
  • Trehalose
  • Povidone