Lack of serological evidence of Middle East respiratory syndrome coronavirus infection in virus exposed camel abattoir workers in Nigeria, 2016

Euro Surveill. 2018 Aug;23(32):1800175. doi: 10.2807/1560-7917.ES.2018.23.32.1800175.

Abstract

BackgroundMiddle East respiratory syndrome coronavirus (MERS-CoV) is a zoonotic threat of global public health concern and dromedary camels are the source of zoonotic infection. Although MERS-CoV is enzootic in dromedaries in Africa as well as the Middle East, zoonotic disease has not been reported in Africa. Methods: In an abattoir in Kano, Nigeria, we tested nasal swabs from camels and investigated 261 humans with repeated occupational exposure to camels, many of whom also reported drinking fresh camel milk (n = 138) or urine (n = 94) or using camel urine for medicinal purposes (n = 96). Results: Weekly MERS-CoV RNA detection in January-February 2016 ranged from 0-8.4% of camels sampled. None of the abattoir workers with exposure to camels had evidence of neutralising antibody to MERS-CoV. Conclusion: There is a need for more studies to investigate whether or not zoonotic transmission of MERS-CoV does take place in Africa.

Keywords: MERS; abattoir; camel; coronavirus; human; occupational exposure; serology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abattoirs*
  • Animals
  • Camelus / virology*
  • Coronavirus / genetics
  • Coronavirus / isolation & purification
  • Coronavirus Infections / transmission
  • Coronavirus Infections / veterinary*
  • Coronavirus Infections / virology*
  • Disease Reservoirs / virology*
  • Humans
  • Middle East Respiratory Syndrome Coronavirus / isolation & purification*
  • Nigeria
  • Occupational Exposure*
  • Zoonoses / diagnosis
  • Zoonoses / epidemiology
  • Zoonoses / transmission
  • Zoonoses / virology*