Abstract
Farnesyl diphosphate synthase/geranylgeranyl diphosphate synthase (FPPS/GGPPS) is a key enzyme in the synthesis of isoprenic chains. Risedronate, a bisphosphonate containing nitrogen (N-BP), is a potent inhibitor of blood stage Plasmodium. Here, we show that P. falciparum parasites overexpressing FPPS/GGPPS are more resistant to risedronate, suggesting that this enzyme is an important target, and bisphosphonate analogues can be used as potential antimalarial drugs.
MeSH terms
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Analysis of Variance
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Animals
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Antimalarials / analysis
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Antimalarials / pharmacology*
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Blotting, Western
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Drug Resistance
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Farnesyltranstransferase / analysis
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Farnesyltranstransferase / biosynthesis*
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Plasmodium falciparum / drug effects*
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Plasmodium falciparum / enzymology*
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Plasmodium falciparum / growth & development
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Reference Values
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Risedronic Acid / analysis
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Risedronic Acid / pharmacology*
Substances
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Antimalarials
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Farnesyltranstransferase
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Risedronic Acid