Moyamoya angiopathy: early postoperative course within 3 months after STA-MCA-bypass surgery in Europe-a retrospective analysis of 64 procedures

J Neurol. 2018 Oct;265(10):2370-2378. doi: 10.1007/s00415-018-8997-2. Epub 2018 Aug 17.

Abstract

Background: Despite the consensus on the necessity of revascularizing surgery in Moyamoya angiopathy in Asia, the indication in Caucasian Moyamoya patients is discussed controversially.

Objective: The safety of revascularizing surgery in Europe should be clarified.

Methods: This study retrospectively analyzed the rate of complications as well as clinical symptoms within the first 3 months after bypass surgery between superficial temporal artery and middle cerebral artery (STA-MCA).

Results: 64 direct bypass procedures in 45 patients (95.5% Caucasians) were analyzed. The magnetic resonance imaging at day 6 showed subdural hematoma in 60.3%. The mean diameter of these hematomas on magnetic resonance imaging was 5.1 mm (SD 3.4 mm) and increased in 25% at follow-up. No difference was found between those patients with early (day 1) or late (day 7) restarts of antiplatelet therapy. Magnetic resonance imaging at day 6 revealed hyperperfusion syndrome after six of 64 procedures (9.3%). Three of these six had clinical symptoms; two-thirds were transient within seconds. Magnetic resonance imaging depicted stroke after seven procedures (10.9%). Five of these seven patients had no new symptoms. Altogether, after ten procedures (15%), patients complained about clinical symptoms. These were all transient. No new transient ischemic attacks occurred during the 3 month follow-up and no new lesions were detected in magnetic resonance imaging. Only two patients underwent surgery for asymptomatic subdural hematoma. All other subdural hematomas resolved spontaneously.

Conclusion: Revasculating surgery is a safe procedure in Caucasian patients with Moyamoya angiopathy. The observed complications have a good prognosis.

Keywords: Caucasians; Early postoperative course; Moyamoya angiopathy; Risks; Subdural hematoma.

MeSH terms

  • Adolescent
  • Adult
  • Cerebral Revascularization*
  • Europe
  • Female
  • Humans
  • Male
  • Middle Aged
  • Middle Cerebral Artery / diagnostic imaging
  • Middle Cerebral Artery / surgery*
  • Moyamoya Disease / diagnostic imaging
  • Moyamoya Disease / physiopathology
  • Moyamoya Disease / surgery*
  • Platelet Aggregation Inhibitors / therapeutic use
  • Postoperative Complications
  • Prognosis
  • Retrospective Studies
  • Temporal Arteries / diagnostic imaging
  • Temporal Arteries / surgery*
  • White People
  • Young Adult

Substances

  • Platelet Aggregation Inhibitors