Impact of 13Valent Vaccine for Prevention of Pneumococcal Diseases in Children and Adults at Risk: Possible Scenarios in Campania Region

Infect Disord Drug Targets. 2019;19(4):403-408. doi: 10.2174/1871526518666180820161630.

Abstract

Background: Pneumonias are the most frequent infectious diseases, characterized by a high prevalence especially among children and adults at risk. The socio-economic impact caused by Streptococcus pneumoniae is evaluated in terms of morbidity, death rate and hospitalizations.

Objective: The aim of the study was to demonstrate the potential economic advantages by implementation of an active anti-pneumococcal 13-valent vaccine strategy in Campania region (Southern Italy) in two different categories of subjects, children (aged 0-12), and adults (aged 50- 79) at risk (hypertension, nephropathies, COPD and heart diseases).

Methods: Vaccination costs were compared with costs necessary to treat avoidable diseases in the presence and absence of a vaccination program.

Results: Offering anti-pneumococcal 13-valent vaccine to the paediatric population was quantified as saving one million euros for Italian national health service in two years. In addition, offering anti-pneumococcal vaccine to adults at risk would generate a return of around 29 million euros.

Conclusion: In both cases, offering anti-pneumococcal 13-valent vaccine was proven to be a helpful political health strategy, not only in consideration of a reduction of cases but also in view of the favourable economic impacts.

Keywords: 13-valent vaccine; Pneumococcal disease; Streptococcus pneumoniae; bacterium; budget impact analysis; etiologic agent..

MeSH terms

  • Aged
  • Child
  • Child, Preschool
  • Hospitalization / economics*
  • Hospitalization / statistics & numerical data
  • Humans
  • Infant
  • Infant, Newborn
  • Italy
  • Middle Aged
  • Pneumococcal Infections / economics
  • Pneumococcal Infections / prevention & control*
  • Pneumococcal Vaccines / administration & dosage*
  • Pneumococcal Vaccines / immunology
  • State Medicine / economics
  • State Medicine / statistics & numerical data
  • Vaccination / economics*
  • Vaccination / statistics & numerical data

Substances

  • 13-valent pneumococcal vaccine
  • Pneumococcal Vaccines