Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA

Lucie Delemotte

doi:10.1085/jgp.201812161

Opening leads to closing: Allosteric crosstalk between the activation and inactivation gates in KcsA

J Gen Physiol. 2018 Oct 1;150(10):1356-1359. doi: 10.1085/jgp.201812161. Epub 2018 Aug 24.

Author

Lucie Delemotte¹

Affiliation

¹ Department of Applied Physics, Science for Life Laboratory, KTH Royal Institute of Technology, Stockholm, Sweden.

Abstract

Delemotte appraises new computational work revealing that the intracellular activation gate must open for C-type inactivation to occur in K⁺ channels.

Publication types

Comment

MeSH terms

Constriction
Ion Channel Gating*
Potassium Channels*
Protein Conformation

Substances

Potassium Channels