High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore

Ayesha J Verrall; David C Lye; Surinder Pada; Nares Smitasin; Chun-Kiat Lee; Mui-Joo Khoo; Evelyn S Koay; Yee-Sin Leo; Dale A Fisher; Sophia Archuleta

doi:10.1093/ofid/ofy171

High Yield of HIV Testing in Dengue-Like Febrile Illness in Singapore

Open Forum Infect Dis. 2018 Jul 13;5(8):ofy171. doi: 10.1093/ofid/ofy171. eCollection 2018 Aug.

Authors

Ayesha J Verrall^{1

2}, David C Lye^{3

4

5}, Surinder Pada⁶, Nares Smitasin¹, Chun-Kiat Lee⁷, Mui-Joo Khoo⁷, Evelyn S Koay^{7

8}, Yee-Sin Leo^{3

4

5

9}, Dale A Fisher^{1

4}, Sophia Archuleta^{1

4}

Affiliations

¹ Division of Infectious Diseases, National University Hospital, Singapore.
² Department of Pathology, University of Otago, Wellington, New Zealand.
³ Institute of Infectious Diseases and Epidemiology, Tan Tock Seng Hospital, Singapore.
⁴ Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁵ Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.
⁶ Division of Medicine, Ng Teng Fong General Hospital, Singapore.
⁷ Department of Laboratory Medicine, National University Hospital, Singapore.
⁸ Department of Pathology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
⁹ Saw Swee Hock School of Public Health, National University of Singapore, Singapore.

Abstract

Where dengue virus infections are endemic, acute febrile illness is often managed as dengue fever (DF) without diagnostic testing. In a prospective study of 140 patients with clinical features of DF, 3 (2.1%) had acute HIV infection (AHI). We recommend testing for AHI in dengue-like febrile illness.

Keywords: acute HIV; acute febrile illness; dengue; diagnostics; fourth-generation enzyme immunoassays.