Fluid resuscitation associated with elevated angiopoietin-2 and length of mechanical ventilation after cardiac surgery

Crit Care Resusc. 2018 Sep;20(3):198-208.

Abstract

Background: Fluid restriction in patients with acute respiratory distress syndrome increases ventilator-free days while lowering plasma angiopoietin-2 (Ang-2), a marker of pulmonary endothelial injury. We hypothesised that fluid resuscitation may lead to endothelial injury after cardiac surgery and analysed Ang-2, angiopoietin-1 (Ang-1) and phospholipase A2 (PLA2) levels and the impact of fluid management on ventilation time.

Methods: Patients enrolled in a single-centre, prospectively randomised interventional study of liberal or conservative fluid resuscitation strategy had plasma Ang-2, Ang-1 and PLA2 levels measured at baseline (pre-operative), 6 and 24 hours after commencement of cardiopulmonary bypass, and analysed by linear mixed models as liberal v conservative (intention to treat) or high v low fluid group (actual treatment, ≥ 3250 mL of fluid administered), and further subclassified as EuroSCORE (European System for Cardiac Operative Risk Evaluation) II ≥ 0.9 or < 0.9.

Results: Over 9 months, 144 patients were randomly allocated to either liberal (n =74) or conservative (n =70) fluid. Patients in the liberal fluid arm tended to an increased Ang-2 (P =0.12) and had higher PLA2 levels (P =0.03). Based on actual fluid administered, Ang-2 levels were higher, the Ang-1/Ang-2 ratio lower, and the length of mechanical ventilation and intensive care unit (ICU) stay was longer in the high fluid group (P < 0.001). The highest levels of Ang- 2 and corresponding lowest Ang-1/Ang-2 ratio, along with longest length of mechanical ventilation and ICU stay, were found with both the liberal and high fluid groups in patients with a EuroSCORE II ≥ 0.9 (P < 0.01).

Conclusion: Liberal fluid resuscitation after cardiac surgery was associated with both pulmonary endothelial injury and prolonged length of mechanical ventilation.

Clinical trial registration: ACTRN12612000754842.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Angiopoietin-1 / blood
  • Angiopoietin-2 / blood*
  • Cardiac Surgical Procedures*
  • Endothelium, Vascular / injuries
  • Female
  • Fluid Therapy / methods*
  • Humans
  • Intensive Care Units
  • Length of Stay / statistics & numerical data
  • Male
  • Middle Aged
  • P-Selectin / blood
  • Phospholipases A2 / blood
  • Prospective Studies
  • Respiration, Artificial / statistics & numerical data*

Substances

  • ANGPT1 protein, human
  • Angiopoietin-1
  • Angiopoietin-2
  • P-Selectin
  • Phospholipases A2