Dietary Interventions and Type 2 Diabetes in Youth: a Fresh Look at the Evidence

Curr Nutr Rep. 2018 Dec;7(4):227-234. doi: 10.1007/s13668-018-0241-2.

Abstract

Purpose of review: The incidence of type 2 diabetes among children and adolescents has sharply increased, highly influenced by prevalence of obesity in youth. Here, we provide an overview of the pathogenesis of diabetes, and summarize recent dietary interventions investigating effects of diet on metabolic risk factors in overweight and obese youth.

Recent findings: Seven dietary interventions were identified randomly assigning participants to weekly or bi-weekly dietary counseling sessions over 12-24-week period, with mixed results. Four interventions showed significant reductions in fasting insulin and insulin resistance levels relative to baseline concentrations ranging from 26 to 50%. Recent evidence is mixed, with four studies showing improvements to insulin concentrations and insulin resistance in obese children and adolescents associated with energy restriction and/or change to carbohydrate consumption. Further work is needed to investigate long-term effects of dietary factors including carbohydrate quality and energy restriction on metabolic health and diabetes prevention early in life.

Keywords: Adolescents; Diabetes; Diet; Dietary interventions; Youth.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Adiposity
  • Adolescent
  • Age Distribution
  • Blood Glucose / metabolism
  • Caloric Restriction
  • Child
  • Child Nutritional Physiological Phenomena
  • Diabetes Mellitus, Type 2 / blood
  • Diabetes Mellitus, Type 2 / diagnosis
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / physiopathology
  • Diet, Healthy*
  • Evidence-Based Medicine
  • Female
  • Humans
  • Incidence
  • Insulin / blood
  • Insulin Resistance
  • Male
  • Nutritional Status
  • Pediatric Obesity / diagnosis
  • Pediatric Obesity / diet therapy*
  • Pediatric Obesity / epidemiology
  • Pediatric Obesity / physiopathology
  • Prevalence
  • Protective Factors
  • Randomized Controlled Trials as Topic
  • Risk Factors
  • Risk Reduction Behavior*

Substances

  • Blood Glucose
  • Insulin