Utility of prenatal MRI in the evaluation and management of fetal ventriculomegaly

J Perinatol. 2018 Nov;38(11):1444-1452. doi: 10.1038/s41372-018-0208-6. Epub 2018 Aug 29.

Abstract

Objective: Fetal ventriculomegaly may occur in isolation or as part of a broader syndrome. We aimed to determine the added value of magnetic resonance imaging (MRI) for informing the pre-natal and postnatal care of pregnancies complicated by ventriculomegaly (VM).

Study design: Retrospective analysis of all cases of prenatally diagnosed VM referred to the fetal center at Lucile Packard Children's Hospital Stanford 1/1/2009-6/1/2014 were reviewed. Ultrasound (US) and MRI findings were reviewed, and the added yield of MRI evaluated.

Results: A total of 91 cases of fetal VM were identified and 74 (81%) underwent MRI. In 62/74 (84%) cases, additional CNS or non-CNS findings, not seen on US, were discovered on MRI, of which 58 were CNS-related. Forty-six (62%) of the additional findings were considered clinically relevant, of which 45 were CNS-related.

Conclusion: Fetal MRI identifies additional, clinically relevant CNS and non-CNS findings in a majority of cases of VM following initial US.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • California / epidemiology
  • Female
  • Humans
  • Hydrocephalus / diagnostic imaging*
  • Hydrocephalus / epidemiology
  • Logistic Models
  • Magnetic Resonance Imaging*
  • Pregnancy
  • Prenatal Diagnosis / methods
  • Retrospective Studies
  • Ultrasonography, Prenatal