Abstract
We examined the correlations between cerebrospinal fluid (CSF) concentrations of homovanillic acid (HVA) and 5-hydroxyindole acetic acid (5-HIAA) and imaging assessment scores, using 123I-Ioflupane SPECT and 123I-MIBG myocardial scintigraphy in 23 drug naïve PD patients. The CSF 5-HIAA concentration correlated with the H/M ratio of the delayed image (r = 0.458, p < 0.05) and the washout rate (r = - 0.642, p < 0.01) of 123I-MIBG myocardial scintigraphy. These correlations suggest some unclarified pathophysiological links between the central serotonergic and cardiac sympathetic systems.
Keywords:
123I-meta-iodobenzylguanidine myocardial scintigraphy; 5-Hydroxyindoleacetic acid; Biomarker; Cerebrospinal fluid; Lewy body; Parkinson’s disease.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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3-Iodobenzylguanidine / pharmacokinetics*
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Aged
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Aged, 80 and over
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Autonomic Fibers, Postganglionic / metabolism
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Biomarkers
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Cognitive Dysfunction / etiology
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Dementia / etiology
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Female
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Heart Conduction System / physiopathology
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Homovanillic Acid / cerebrospinal fluid
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Humans
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Hydroxyindoleacetic Acid / cerebrospinal fluid*
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Iodine Radioisotopes / pharmacokinetics*
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Male
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Middle Aged
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Myocardial Perfusion Imaging*
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Myocardium / metabolism*
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Nortropanes / pharmacokinetics*
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Organ Specificity
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Parkinson Disease / cerebrospinal fluid
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Parkinson Disease / metabolism*
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Parkinson Disease / psychology
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Radiopharmaceuticals / pharmacokinetics*
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Serotonin / metabolism
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Tomography, Emission-Computed, Single-Photon*
Substances
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Biomarkers
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Iodine Radioisotopes
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Nortropanes
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Radiopharmaceuticals
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Serotonin
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3-Iodobenzylguanidine
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Hydroxyindoleacetic Acid
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Iodine-123
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ioflupane
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Homovanillic Acid