Coronary artery calcium and intima-media thickness are associated with level of cytomegalovirus immunoglobulin G in HIV-infected patients

HIV Med. 2019 Jan;20(1):60-62. doi: 10.1111/hiv.12672. Epub 2018 Sep 4.

Abstract

Coinfection with cytomegalovirus (CMV) may be involved in cardiovascular disease in HIV-infected patients. We found that higher level of CMV immunoglobulin G (IgG) was independently associated with an increased risk of coronary artery calcium and higher intima-media thickness in HIV-infected patients but not in healthy controls after adjustment for other cardiovascular risk factors and levels of herpes viridae IgG.

Keywords: HIV infection; atherosclerosis; cardiovascular disease; coronary artery calcium; cytomegalovirus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Calcium / metabolism
  • Carotid Arteries / diagnostic imaging*
  • Carotid Intima-Media Thickness
  • Case-Control Studies
  • Coinfection
  • Cross-Sectional Studies
  • Cytomegalovirus / immunology*
  • Cytomegalovirus Infections / immunology*
  • Female
  • HIV Infections / complications
  • HIV Infections / immunology*
  • Humans
  • Immunoglobulins, Intravenous / metabolism*
  • Male
  • Middle Aged
  • Risk Factors

Substances

  • Immunoglobulins, Intravenous
  • cytomegalovirus-specific hyperimmune globulin
  • Calcium