T Cell Metabolism Has Evolved to Tolerate Tuberculosis

Valerie A C M Koeken; Reinout van Crevel; Mihai G Netea

doi:10.1016/j.cmet.2018.08.015

T Cell Metabolism Has Evolved to Tolerate Tuberculosis

Cell Metab. 2018 Sep 4;28(3):332-333. doi: 10.1016/j.cmet.2018.08.015.

Authors

Valerie A C M Koeken¹, Reinout van Crevel¹, Mihai G Netea²

Affiliations

¹ Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands.
² Department of Internal Medicine and Radboud Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands; Department of Genomics and Immunoregulation, Life and Medical Sciences Institute (LIMES), University of Bonn, Bonn, Germany. Electronic address: [email protected].

PMID: 30184482
DOI: 10.1016/j.cmet.2018.08.015

Abstract

Although T cells are important in preventing tuberculosis progression, their role in disease tolerance is unknown. Recently in Science Immunology, Tzelepis et al. (2018) have revealed that mitochondrial cyclophilin D controls T cell metabolism and proliferation, contributing to tolerance. Cyclophilin D loss leads to immunopathology and increased mortality, without impacting bacterial burden.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Cyclophilins
Humans
Mitochondria
Peptidyl-Prolyl Isomerase F
T-Lymphocytes*
Tuberculosis*

Substances

Peptidyl-Prolyl Isomerase F
Cyclophilins