Abstract
Expression of type I and II interferon (IFN) was evaluated in gut-associated lymphoid tissue (GALT) and peripheral blood mononuclear cells (PBMCs) of HIV-1-positive patients on long-term, suppressive, antiretroviral therapy before and after probiotic supplementation. IFNα subtypes and IFNβ were expressed at higher levels in GALT compared to PBMC, whereas an opposite trend of expression was recorded for IFNγ. An increase of IFNα6, IFNα10, IFNα14, IFNα17, and IFNα21 and a decrease of IFNγ were observed in both anatomical sites after probiotic supplementation.
MeSH terms
-
Adult
-
Anti-Retroviral Agents / therapeutic use
-
Dietary Supplements
-
Disease Progression
-
Gene Expression Regulation
-
HIV Infections / drug therapy
-
HIV Infections / immunology*
-
HIV-1 / immunology*
-
Humans
-
Interferon-alpha / genetics
-
Interferon-alpha / metabolism*
-
Interferon-beta / genetics
-
Interferon-beta / metabolism*
-
Interferon-gamma / genetics
-
Interferon-gamma / metabolism*
-
Intestinal Mucosa / physiology*
-
Leukocytes, Mononuclear / physiology*
-
Male
-
Middle Aged
-
Probiotics / therapeutic use*
-
Young Adult
Substances
-
Anti-Retroviral Agents
-
Interferon-alpha
-
Interferon-beta
-
Interferon-gamma