Abstract
Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Cells, Cultured
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Deltaretrovirus / drug effects*
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Drug Synergism
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Foscarnet
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Humans
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Interferon Type I / pharmacology*
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Lymphocytes / microbiology
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Organophosphorus Compounds / pharmacology*
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Phosphonoacetic Acid / analogs & derivatives
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Phosphonoacetic Acid / pharmacology*
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Recombinant Proteins / pharmacology
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Virus Replication / drug effects*
Substances
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Interferon Type I
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Organophosphorus Compounds
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Recombinant Proteins
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Foscarnet
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Phosphonoacetic Acid