Synergistic inhibition of human T-cell lymphotropic virus type III replication in vitro by phosphonoformate and recombinant alpha-A interferon

Antimicrob Agents Chemother. 1986 Jul;30(1):189-91. doi: 10.1128/AAC.30.1.189.

Abstract

Phosphonoformate and recombinant alpha-A interferon synergistically inhibited the replication of human T-cell lymphotropic virus type III in cultured peripheral blood lymphocytes. T-cell proliferative capability was maintained by this combination, and toxicity was minimal.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cells, Cultured
  • Deltaretrovirus / drug effects*
  • Drug Synergism
  • Foscarnet
  • Humans
  • Interferon Type I / pharmacology*
  • Lymphocytes / microbiology
  • Organophosphorus Compounds / pharmacology*
  • Phosphonoacetic Acid / analogs & derivatives
  • Phosphonoacetic Acid / pharmacology*
  • Recombinant Proteins / pharmacology
  • Virus Replication / drug effects*

Substances

  • Interferon Type I
  • Organophosphorus Compounds
  • Recombinant Proteins
  • Foscarnet
  • Phosphonoacetic Acid