Revert the SIRT: Normalizing SIRT1 Activity in Myelodysplastic Stem Cells

Cell Stem Cell. 2018 Sep 6;23(3):315-317. doi: 10.1016/j.stem.2018.08.003.

Abstract

Myelodysplastic syndromes are hematologic malignancies with few treatment options and a propensity to transform to acute myeloid leukemia. In this issue of Cell Stem Cell, Sun et al. (2018) report that low SIRT1 levels in myelodysplastic stem cells contribute to aberrant self-renewal through enabling hyperacetylation and reduced activity of TET2.

Publication types

  • Comment

MeSH terms

  • DNA-Binding Proteins
  • Dioxygenases
  • Hematologic Neoplasms*
  • Humans
  • Leukemia, Myeloid, Acute*
  • Myelodysplastic Syndromes*
  • Proto-Oncogene Proteins
  • Sirtuin 1
  • Stem Cells

Substances

  • DNA-Binding Proteins
  • Proto-Oncogene Proteins
  • Dioxygenases
  • TET2 protein, human
  • SIRT1 protein, human
  • Sirtuin 1