Myocardial hypersensitivity to ischemic injury is not reversed by clonidine or propranolol in a predator-based rat model of posttraumatic stress disorder

Prog Neuropsychopharmacol Biol Psychiatry. 2019 Mar 8:89:117-124. doi: 10.1016/j.pnpbp.2018.09.003. Epub 2018 Sep 5.

Authors

Boyd R Rorabaugh¹, Albert D Bui², Sarah L Seeley², Eric D Eisenmann³, Robert M Rose³, Brandon L Johnson³, Madelaine R Huntley³, Megan E Heikkila³, Phillip R Zoladz³

Affiliations

¹ Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, Ohio Northern University, Ada, OH, USA. Electronic address: [email protected].
² Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, Ohio Northern University, Ada, OH, USA.
³ Department of Psychology, Sociology, & Criminal Justice, Ohio Northern University, Ada, OH, USA.

No abstract available

Keywords: Adrenergic; Anxiety; Heart; Ischemia; Posttraumatic stress disorder; Sympathetic.

Copyright © 2018 Elsevier Inc. All rights reserved.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Adrenergic Agents / pharmacology*
Animals
Anxiety / drug therapy
Anxiety / pathology
Anxiety / physiopathology
Cardiovascular Agents / pharmacology*
Clonidine / pharmacology*
Disease Models, Animal
Disease Susceptibility
Heart / drug effects
Heart / physiopathology
Male
Myocardial Ischemia / drug therapy*
Myocardial Ischemia / pathology
Myocardial Ischemia / physiopathology
Myocardium
Propranolol / pharmacology*
Random Allocation
Rats, Sprague-Dawley
Stress Disorders, Post-Traumatic / drug therapy
Stress Disorders, Post-Traumatic / pathology
Stress Disorders, Post-Traumatic / physiopathology*
Sympathetic Nervous System / drug effects
Sympathetic Nervous System / physiopathology
Treatment Failure

Substances

Adrenergic Agents
Cardiovascular Agents
Propranolol
Clonidine

Grants and funding

R15 HL132322/HL/NHLBI NIH HHS/United States