Cerebral White Matter Hyperintensities and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature

J Fladt; C Kronlage; G M De Marchis

doi:10.1016/j.neulet.2018.09.003

Cerebral White Matter Hyperintensities and Microbleeds in Acute Ischemic Stroke: Impact on Recanalization Therapies. A Review of the Literature

Neurosci Lett. 2018 Nov 20:687:55-64. doi: 10.1016/j.neulet.2018.09.003. Epub 2018 Sep 5.

Authors

J Fladt¹, C Kronlage¹, G M De Marchis²

Affiliations

¹ Department of Neurology, University Hospital Basel, Switzerland.
² Department of Neurology, University Hospital Basel, Switzerland. Electronic address: [email protected].

PMID: 30194982
DOI: 10.1016/j.neulet.2018.09.003

Abstract

Cerebral white matter hyperintensities (WMH) and cerebral microbleeds (CMBs) are frequently seen on brain imaging acquired for acute ischemic stroke. Given the raising use of recanalization therapies - both intravenous and endovascular - the interest on the impact of WMH and CMBs on the risk of intracerebral hemorrhage and on functional outcome is growing. In this review, we will discuss the relevance of WMH and CMBs among patients with an acute ischemic stroke, focusing on the implications for recanalization therapies.

Keywords: Cerebral microbleeds; Cerebral small vessel disease; Cerebral white matter disease; Cerebral white matter hyperintensities; Leukoaraiosis; Recanalization therapies; White matter lesions.

Publication types

Review

MeSH terms

Animals
Brain Ischemia / diagnostic imaging*
Brain Ischemia / surgery
Cerebral Hemorrhage / diagnostic imaging*
Cerebral Hemorrhage / surgery
Cerebral Revascularization / methods*
Humans
Magnetic Resonance Imaging / methods
Microvessels / diagnostic imaging*
Microvessels / surgery
Stroke / diagnostic imaging*
Stroke / surgery
White Matter / diagnostic imaging*
White Matter / surgery