Randomized controlled trial of a positive affect intervention for methamphetamine users

Drug Alcohol Depend. 2018 Nov 1:192:8-15. doi: 10.1016/j.drugalcdep.2018.07.029. Epub 2018 Sep 5.

Abstract

Background: Contingency management (CM) is an evidence-based intervention providing rewards in exchange for biomarkers that confirm abstinence from stimulants such as methamphetamine. We tested the efficacy of a positive affect intervention designed to boost the effectiveness of CM with HIV-positive, methamphetamine-using sexual minority men.

Methods: This attention-matched, randomized controlled trial of a positive affect intervention delivered during CM was registered on www.clinicaltrials.gov (NCT01926184). In total, 110 HIV-positive sexual minority men with biologically confirmed, recent methamphetamine use were enrolled. Five individual sessions of a positive affect intervention (n = 55) or an attention-control condition (n = 55) were delivered during three months of CM. Secondary outcomes examined over the 3-month intervention period included: 1) psychological processes relevant to affect regulation (i.e., positive affect, negative affect, and mindfulness); 2) methamphetamine craving; 3) self-reported stimulant use (past 3 months); and 4) cumulative number of urine samples that were non-reactive for stimulants (i.e., methamphetamine and cocaine) during CM.

Results: Those randomized to the positive affect intervention reported significant increases in positive affect during individual sessions and increases in mindfulness over the 3-month intervention period. Intervention-related improvements in these psychological processes relevant to affect regulation were paralleled by concurrent decreases in methamphetamine craving and self-reported stimulant use over the 3-month intervention period.

Conclusions: Delivering a positive affect intervention may improve affect regulation as well as reduce methamphetamine craving and stimulant use during CM with HIV-positive, methamphetamine-using sexual minority men.

Keywords: Contingency management; HIV; Men who have sex with men; Methamphetamine; Mindfulness; Positive affect.

Publication types

  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Amphetamine-Related Disorders / psychology*
  • Amphetamine-Related Disorders / therapy*
  • Amphetamine-Related Disorders / urine
  • Behavior Therapy / methods
  • Central Nervous System Stimulants / urine
  • Early Intervention, Educational / methods*
  • Follow-Up Studies
  • HIV Seropositivity / psychology
  • HIV Seropositivity / therapy
  • HIV Seropositivity / urine
  • Homosexuality, Male / psychology*
  • Humans
  • Male
  • Methamphetamine* / urine
  • Middle Aged
  • Mindfulness / methods
  • Reward
  • Sexual and Gender Minorities / psychology*

Substances

  • Central Nervous System Stimulants
  • Methamphetamine

Associated data

  • ClinicalTrials.gov/NCT01926184