Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML

Hannah J Uckelmann; Scott A Armstrong; Richard M Stone

doi:10.1016/j.ccell.2018.08.013

Location, Location, Location: Mutant NPM1c Cytoplasmic Localization Is Required to Maintain Stem Cell Genes in AML

Cancer Cell. 2018 Sep 10;34(3):355-357. doi: 10.1016/j.ccell.2018.08.013.

Authors

Hannah J Uckelmann¹, Scott A Armstrong¹, Richard M Stone²

Affiliations

¹ Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: [email protected].

PMID: 30205041
DOI: 10.1016/j.ccell.2018.08.013

Abstract

In this issue of Cancer Cell, Brunetti and colleagues elucidate the role of mutant NPM1c and its cytoplasmic mislocalization in acute myeloid leukemia. They demonstrate how mutant-specific degradation or relocalization leads to a loss of the stem cell signature characteristic of these leukemias and induces their differentiation.

Publication types

Comment

MeSH terms

Cell Differentiation
Cytoplasm
Humans
Leukemia, Myeloid, Acute*
Nuclear Proteins*
Stem Cells

Substances

Nuclear Proteins

Grants and funding

P50 CA206963/CA/NCI NIH HHS/United States