Massive increase in monocyte HLA-DR expression can be used to discriminate between septic shock and hemophagocytic lymphohistiocytosis-induced shock

Crit Care. 2018 Sep 11;22(1):213. doi: 10.1186/s13054-018-2146-2.

Solenn Remy¹, Morgane Gossez^{2

3}, Alexandre Belot^{4

5}, Jack Hayman², Aurelie Portefaix⁶, Fabienne Venet^{2

3}, Etienne Javouhey¹, Guillaume Monneret^{7

8

9}

¹ Hospices Civils de Lyon, Paediatric Intensive Care Unit, Mother and Children University Hospital, 59 Boulevard Pinel, 69500, Bron, France.
² Hospices Civils de Lyon, Immunology Laboratory, E. Herriot Hospital, 69003, Lyon, France.
³ EA 7426, Pathophysiology of injury-induced immunosuppression (University Claude Bernard Lyon 1, BioMérieux, Hospices Civils de Lyon), E. Herriot Hospital, 69003, Lyon, France.
⁴ Hospices Civils de Lyon, Paediatric Nephrology, Rheumatology, Dermatology Unit, National Referee Centre for pediatric-onset Rheumatism and autoimmune diseases (RAISE), Mother and Children University Hospital, 59 Boulevard Pinel, 69500, Bron, France.
⁵ Université de Lyon, INSERM U1111, CIRI, Lyon, France.
⁶ EPICIME-CIC 1407 de Lyon, Inserm, Service de Pharmacologie Clinique, CHU-Lyon, Bron, France.
⁷ Hospices Civils de Lyon, Immunology Laboratory, E. Herriot Hospital, 69003, Lyon, France. [email protected].
⁸ EA 7426, Pathophysiology of injury-induced immunosuppression (University Claude Bernard Lyon 1, BioMérieux, Hospices Civils de Lyon), E. Herriot Hospital, 69003, Lyon, France. [email protected].
⁹ Cellular Immunology Laboratory, Hôpital E. Herriot - Hospices Civils de Lyon, France Pavillon E - 5 place d'Arsonval, 69437, Lyon, Cedex 03, France. [email protected].

No abstract available

Keywords: Biomarker; Hemophagocytic lymphohistiocytosis; Immune response; Septic shock.

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