The complement system in glioblastoma multiforme

T A M Bouwens van der Vlis; J M Kros; D A M Mustafa; R T A van Wijck; L Ackermans; P M van Hagen; P J van der Spek

doi:10.1186/s40478-018-0591-4

The complement system in glioblastoma multiforme

Acta Neuropathol Commun. 2018 Sep 12;6(1):91. doi: 10.1186/s40478-018-0591-4.

Authors

T A M Bouwens van der Vlis^{1

2

3}, J M Kros⁴, D A M Mustafa³, R T A van Wijck⁵, L Ackermans², P M van Hagen^{5

6}, P J van der Spek^{1

3}

Affiliations

¹ Department of Bioinformatics, Erasmus University Medical Center, Wytemaweg 80, 3015, GE, Rotterdam, The Netherlands.
² Department of Neurosurgery, Maastricht University Medical Center, P. Debyelaan 25, 6229, HX, Maastricht, The Netherlands.
³ Department of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3015, GE, Rotterdam, The Netherlands.
⁴ Department of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3015, GE, Rotterdam, The Netherlands. [email protected].
⁵ Department of Internal Medicine, Erasmus University Medical Center, Wytemaweg 80, 3015, GE, Rotterdam, The Netherlands.
⁶ Department of Immunology, Erasmus University Medical Center, Wytemaweg 80, 3015, GE, Rotterdam, The Netherlands.

Abstract

The human complement system is represents the main effector arm of innate immunity and its ambivalent function in cancer has been subject of ongoing dispute. Glioma stem-like cells (GSC) residing in specific niches within glioblastomas (GBM) are capable of self-renewal and tumor proliferation. Recent data are indicative of the influence of the complement system on the maintenance of these cells. It appears that the role of the complement system in glial tumorigenesis, particularly its influence on GSC niches and GSC maintenance, is significant and warrants further exploration for therapeutic interventions.

Publication types

Review

MeSH terms

Brain Neoplasms / metabolism*
Brain Neoplasms / pathology
Complement System Proteins / metabolism*
Glioblastoma / metabolism*
Glioblastoma / pathology
Humans
Neoplastic Stem Cells / metabolism*

Substances

Complement System Proteins