Abstract
Beta-lactam therapy for severe staphylococcal infections is associated with superior outcomes, compared to non-beta-lactam therapy. For patients with immediate hypersensitivity to beta-lactams, desensitization has been widely employed to allow beta-lactam therapy, but published protocols for antistaphylococcal beta-lactams such as flucloxacillin are lacking. Here, we report a case and describe the desensitization protocol successfully used for a patient with isolated flucloxacillin immediate hypersensitivity, for whom a penicillin desensitization protocol would likely have resulted in an adverse drug reaction.
Keywords:
anaphylaxis; antibiotic allergy; desensitization; flucloxacillin; hypersensitivity; penicillin allergy.
© Crown copyright 2018.
MeSH terms
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Anti-Bacterial Agents / administration & dosage*
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Anti-Bacterial Agents / adverse effects
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Desensitization, Immunologic / methods*
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Drug Administration Schedule
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Drug Hypersensitivity / etiology
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Drug Hypersensitivity / immunology
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Drug Hypersensitivity / physiopathology
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Drug Hypersensitivity / prevention & control*
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Drug Monitoring
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Endocarditis, Bacterial / drug therapy*
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Endocarditis, Bacterial / immunology
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Endocarditis, Bacterial / microbiology
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Floxacillin / administration & dosage*
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Floxacillin / adverse effects
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Humans
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Injections, Intravenous
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Male
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Middle Aged
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Staphylococcal Infections / drug therapy*
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Staphylococcal Infections / immunology
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Staphylococcal Infections / microbiology
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Staphylococcus aureus / drug effects
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Staphylococcus aureus / growth & development
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Treatment Outcome
Substances
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Anti-Bacterial Agents
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Floxacillin