Integration of genome-wide mRNA and miRNA expression, and DNA methylation data of three cell lines exposed to ten carbon nanomaterials

Giovanni Scala; Veer Marwah; Pia Kinaret; Jukka Sund; Vittorio Fortino; Dario Greco

doi:10.1016/j.dib.2018.05.107

Integration of genome-wide mRNA and miRNA expression, and DNA methylation data of three cell lines exposed to ten carbon nanomaterials

Data Brief. 2018 May 25:19:1046-1057. doi: 10.1016/j.dib.2018.05.107. eCollection 2018 Aug.

Authors

Giovanni Scala^{1

2

3}, Veer Marwah^{1

2}, Pia Kinaret^{1

2

3}, Jukka Sund¹, Vittorio Fortino^{1

2

4}, Dario Greco^{1

2

3}

Affiliations

¹ Faculty of Medicine and Life Sciences, University of Tampere, Finland.
² Institute of Biosciences and Medical Technology (BioMediTech), University of Tampere, Finland.
³ Institute of Biotechnology, University of Helsinki, Finland.
⁴ Institute of Biomedicine, University of Eastern Finland, Kuopio Campus, Finland.

Abstract

We present data derived from an exposure experiment in which three cell-lines representative of cell types of the respiratory tissue (epithelial type-I A549, epithelial type-II BEAS-2B, and macrophage THP-1) have been exposed to ten different carbon-based nanomaterials for 48 h. In particular, we provide: genome-wide mRNA and miRNA expression, and DNA methylation; gene tables, containing information on the aberrations induced in these three genomic data layers at the gene level; mechanism of action (MOA) maps representing the comparative functional alteration induced in each cell line and each exposure.