Is spindle cell oncocytoma a true entity or a variant of pituicytoma? A case report with review of literature

Neurol India. 2018 Sep-Oct;66(5):1413-1418. doi: 10.4103/0028-3886.241353.

Abstract

Spindle cell oncocytoma (SCO) is a newly described rare entity simulating clinicoradiological features of a nonfunctional pituitary adenoma and is corresponding to the category of World Health Organization grade I tumor. However, because of the reported incidence of recurrence and invasive presentation in some cases, its categorization as a low grade tumor is questionable. Earlier, it was thought to arise from the folliculostellate cells of adenohypophysis. Recently, few reports have described expression of thyroid transcription factor-1 [TTF-1], which is a specific marker for pituicytes of neurohypophysis, suggesting this tumor to be a variant of pituicytoma. We describe a case of SCO in a 28-year-old young female patient with TTF-1 immunopositivity, and ultra-structurally showing abundant mitochondria along with few neurosecretory granules.

Keywords: Folliculo-stellate cell; TTF-1; pituicyte; pituitary; spindle cell oncocytoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adenoma, Oxyphilic / metabolism
  • Adenoma, Oxyphilic / pathology*
  • Adult
  • Female
  • Humans
  • Pituitary Neoplasms / metabolism
  • Pituitary Neoplasms / pathology*
  • Thyroid Nuclear Factor 1 / metabolism

Substances

  • Thyroid Nuclear Factor 1