Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer

Kee Siang Lim; Richard W Wong

doi:10.1016/j.chembiol.2018.09.003

Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer

Cell Chem Biol. 2018 Sep 20;25(9):1056-1058. doi: 10.1016/j.chembiol.2018.09.003.

Authors

Kee Siang Lim¹, Richard W Wong²

Affiliations

¹ WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Japan.
² WPI Nano Life Science Institute (WPI-NanoLSI), Kanazawa University, Kakuma-machi, Kanazawa, Japan; Cell-Bionomics Research Unit, Innovative Integrated Bio-Research Core, Institute for Frontier Science Initiative, Kanazawa University, Kanazawa, Japan. Electronic address: [email protected].

PMID: 30241601
DOI: 10.1016/j.chembiol.2018.09.003

Abstract

Nuclear pores are nanomachines acting as gatekeepers of molecular transport across nuclear membranes. In a recent issue of Cell, Rodriguez-Bravo et al. (2018) demonstrates that nuclear pores promote aggressive prostate cancer by snowballing POM121-importin β-driven nuclear import. Treatment with Importazole, an importin β inhibitor, impeded tumor aggressiveness, presenting a potential therapeutic strategy.

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MeSH terms

Active Transport, Cell Nucleus
E2F1 Transcription Factor
Humans
Male
Membrane Glycoproteins
Nuclear Pore Complex Proteins
Nuclear Pore*
Prostatic Neoplasms*
beta Karyopherins

Substances

E2F1 Transcription Factor
E2F1 protein, human
Membrane Glycoproteins
Nuclear Pore Complex Proteins
POM121 protein, human
beta Karyopherins