Tumoral MGMT content predicts survival in patients with aggressive pituitary tumors and pituitary carcinomas given treatment with temozolomide

Endocrine. 2018 Dec;62(3):737-739. doi: 10.1007/s12020-018-1751-9. Epub 2018 Sep 24.
No abstract available

Publication types

  • Letter

MeSH terms

  • Adult
  • Aged
  • Antineoplastic Agents, Alkylating / therapeutic use*
  • DNA Modification Methylases / metabolism*
  • DNA Repair Enzymes / metabolism*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Pituitary Neoplasms / drug therapy
  • Pituitary Neoplasms / metabolism*
  • Pituitary Neoplasms / mortality
  • Pituitary Neoplasms / pathology
  • Prognosis
  • Survival Rate
  • Temozolomide / therapeutic use*
  • Treatment Outcome
  • Tumor Suppressor Proteins / metabolism*

Substances

  • Antineoplastic Agents, Alkylating
  • Tumor Suppressor Proteins
  • DNA Modification Methylases
  • MGMT protein, human
  • DNA Repair Enzymes
  • Temozolomide