The oncometabolite, D-2-hydroxyglutarate, accumulates in various cancers because of acquired mutations in isocitrate dehydrogenase 1 & 2. Here, we describe a new mechanism for D-2-hydroxyglutarate accumulation in breast cancer. It involves c-Myc signaling and alcohol dehydrogenase, iron-containing protein 1 (ADHFE1) and leads to metabolic reprogramming, de-differentiation, and increased mammary tumorigenesis.
Keywords: 2-hydroxyglutarate; Breast Cancer; Mechanisms of oncogenesis and tumor progression; Metabolism; Myc signaling; Oncogenes and tumor suppressor genes; Tumor metabolism; oncogene.