ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

Yan Chen; Yingfei Wang; Weibo Luo

doi:10.1080/23723556.2018.1479619

ZMYND8 is a primary HIF coactivator that mediates breast cancer progression

Mol Cell Oncol. 2018 Aug 1;5(4):e1479619. doi: 10.1080/23723556.2018.1479619. eCollection 2018.

Authors

Yan Chen¹, Yingfei Wang^{1

2}, Weibo Luo^{1

3}

Affiliations

¹ Department of Pathology, UT Southwestern Medical Center, Dallas, Texas, USA.
² Department of Neurology and Neurotherapeutics, UT Southwestern Medical Center, Dallas, Texas, USA.
³ Department of Pharmacology, UT Southwestern Medical Center, Dallas, Texas, USA.

Abstract

Epigenetic regulator plays a pivotal role in breast cancer progression. We recently demonstrated that the epigenetic reader zinc finger MYND-type containing 8 (ZMYND8) mediates breast cancer progression and metastasis by activating hypoxia-inducible factor (HIF). This discovery provides new insights into the molecular mechanism underlying HIF activation and breast cancer progression.

Keywords: Hypoxia-inducible factor; breast cancer; epigenetic reader; gene regulation.

Abstract

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