Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Clinical_Isolates: Algeria

Hanane Yousfi; Linda Hadjadj; Iman Dandachi; Rym Lalaoui; Adil Merah; Kamel Amoura; Ahlem Dahi; Mazouz Dekhil; Naima Messalhi; Seydina M Diene; Sophie Baron; Jean-Marc Rolain

doi:10.1089/mdr.2018.0147

Colistin- and Carbapenem-Resistant Klebsiella pneumoniae Clinical_Isolates: Algeria

Microb Drug Resist. 2019 Mar;25(2):258-263. doi: 10.1089/mdr.2018.0147. Epub 2018 Sep 25.

Authors

Hanane Yousfi¹, Linda Hadjadj¹, Iman Dandachi¹, Rym Lalaoui¹, Adil Merah², Kamel Amoura^{2

3}, Ahlem Dahi^{2

3}, Mazouz Dekhil^{2

3}, Naima Messalhi^{2

3}, Seydina M Diene¹, Sophie Baron¹, Jean-Marc Rolain¹

Affiliations

¹ 1 Aix Marseille University , IRD, APHM, MEPHI, IHU-Mediterranean Infection, Marseille, France .
² 2 Microbiology Department, Annaba University Hospital , Annaba, Algeria .
³ 3 Department of Infectious Diseases, Annaba University Hospital , Annaba, Algeria .

PMID: 30256174
DOI: 10.1089/mdr.2018.0147

Abstract

This study investigates the molecular mechanisms of colistin and carbapenem resistance in Klebsiella pneumoniae ST101 strains. The three K. pneumoniae carried bla_CTX-M-15, bla_TEM-183, and bla_SHV-106 genes and two coharbored bla_OXA-48. As for colistin resistance, the isolates had amino acid substitutions in PmrA/B and a truncated mgrB gene in one isolate.

Keywords: insertion; carbapenem resistance; colistin resistance.

MeSH terms

Algeria / epidemiology
Amino Acid Substitution / genetics
Anti-Bacterial Agents
Carbapenems / pharmacology*
Colistin / pharmacology*
Drug Resistance, Bacterial / drug effects*
Drug Resistance, Bacterial / genetics*
Humans
Klebsiella Infections / epidemiology*
Klebsiella Infections / microbiology*
Klebsiella pneumoniae / drug effects*
Klebsiella pneumoniae / genetics*
Microbial Sensitivity Tests
beta-Lactamases / genetics

Substances

Anti-Bacterial Agents
Carbapenems
beta-Lactamases
oxacillinase
Colistin