Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects

Huimin Feng; Feizai Ha; Guiping Hu; Yonghua Wu; Shanfa Yu; Zhang Ji; Weiyue Feng; Tiancheng Wang; Guang Jia

doi:10.1016/j.jtemb.2018.08.003

Concentration of chromium in whole blood and erythrocytes showed different relationships with serum apolipoprotein levels in Cr(VI) exposed subjects

J Trace Elem Med Biol. 2018 Dec:50:384-392. doi: 10.1016/j.jtemb.2018.08.003. Epub 2018 Aug 15.

Authors

Huimin Feng¹, Feizai Ha², Guiping Hu¹, Yonghua Wu², Shanfa Yu³, Zhang Ji⁴, Weiyue Feng⁵, Tiancheng Wang⁶, Guang Jia⁷

Affiliations

¹ Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China.
² Department of Clinical Laboratory, Third Hospital of Peking University, Beijing, China.
³ Institute of Occupational Medicine of Henan Province, Zhengzhou, Henan Province, China.
⁴ Center for Disease Control and Prevention, Jinan City, Shandong Province, China.
⁵ Laboratory for Bio-Environmental Health Sciences, Institute of High Energy Physics, Chinese Academy of Sciences, Beijing, China.
⁶ Department of Clinical Laboratory, Third Hospital of Peking University, Beijing, China; Medical Research Center, Third Hospital of Peking University, Beijing, China. Electronic address: [email protected].
⁷ Department of Occupational and Environmental Health Sciences, School of Public Health, Peking University, Beijing, China. Electronic address: [email protected].

PMID: 30262309
DOI: 10.1016/j.jtemb.2018.08.003

Abstract

Objective: To explore the effects of hexavalent chromium [Cr(VI)] on apolipoprotein(Apo) metabolism.

Methods: One hundred and six long-term Cr(VI) exposed subjects and fifty five non-exposed individuals were recruited. The blood metals, glucose and lipid parameters were measured to evaluate the effects of hexavalent chromium on the apolipoproteins.

Results: The quantity and homeostasis of multi-elements were significantly different between Cr(VI)exposed subjects and the controls(P < 0.05). The levels of serum TG, FPG, LDL-C, Apo AI, AII, CII, CIII, E and Lp(a) also changed significantly (P < 0.05). Concentration of chromium in whole blood and erythrocytes had different relationships with serum apolipoprotein levels in Cr(VI)exposed subjects.

Conclusions: Exposure of hexavalent chromium could significantly change the homeostasis of multi-elements as well as the levels of serum apolipoproteins. Cr(III) and Cr(VI)may have different effects on the apolipoproteins.

Keywords: Element homeostasis; Hexavalent chromium exposure; Serum lipoprotein metabolism.

MeSH terms

Adult
Apolipoproteins / blood*
Chromium / blood*
Chromium / toxicity
Cross-Sectional Studies
Erythrocytes / drug effects
Erythrocytes / metabolism*
Female
Homeostasis / drug effects
Humans
Male
Middle Aged
Young Adult

Substances

Apolipoproteins
Chromium
chromium hexavalent ion